BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

BACKGROUND: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous studies have shown that the clathrin adaptor Golgi-localized...

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Publicado en:Mol Neurodegener
Autores principales: Kim, WonHee, Ma, Liang, Lomoio, Selene, Willen, Rachel, Lombardo, Sylvia, Dong, Jinghui, Haydon, Philip G., Tesco, Giuseppina
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796504/
https://ncbi.nlm.nih.gov/pubmed/29391027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0239-7
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