Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission

Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) is a monomeric clathrin adaptor that has been shown to regulate the trafficking of the Beta-site APP-cleaving enzyme (BACE1), which is required for production of the Alzheimer’s disease (AD)-associated amyloid βpeptide. Our previous studi...

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Udgivet i:PLoS One
Main Authors: Walker, Kendall R., Modgil, Amit, Albrecht, David, Lomoio, Selene, Haydon, Philip G., Moss, Stephen J., Tesco, Giuseppina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871427/
https://ncbi.nlm.nih.gov/pubmed/27192432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155799
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