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BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus

β-Site amyloid precursor protein-cleaving enzyme (BACE1) is a membrane-tethered member of the aspartyl proteases that has been identified as β-secretase. BACE1 is targeted through the secretory pathway to the plasma membrane and then is internalized to endosomes. Sorting of membrane proteins to the...

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Detalhes bibliográficos
Main Authors: Kang, Eugene L., Biscaro, Barbara, Piazza, Fabrizio, Tesco, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522283/
https://ncbi.nlm.nih.gov/pubmed/23109336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407072
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