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Multiple Evolutionarily Conserved Di-leucine Like Motifs in the Carboxyl Terminus Control the Anterograde Trafficking of NKCC2

Mutations in the apical Na-K-2Cl co-transporter, NKCC2, cause type I Bartter syndrome, a life-threatening kidney disease. Yet the mechanisms underlying the regulation of NKCC2 trafficking in renal cells are scarcely known. We previously showed that naturally occurring mutations depriving NKCC2 of it...

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Detalhes bibliográficos
Main Authors: Zaarour, Nancy, Demaretz, Sylvie, Defontaine, Nadia, Zhu, Yingying, Laghmani, Kamel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522265/
https://ncbi.nlm.nih.gov/pubmed/23105100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399162
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