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CD4(+)CD25(+) T regulatory cells control anti-islet CD8(+) T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes
Pancreatic lymph node-derived CD4(+)CD25(+) T regulatory (Treg) cells inhibit in situ differentiation of islet-reactive CD8(+) T cells into cytotoxic T lymphocytes, thereby preventing diabetes progression. The mechanism by which these Treg cells suppress anti-islet CD8(+) T cells is unknown. Here, w...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196896/ https://ncbi.nlm.nih.gov/pubmed/12949259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834400100 |
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