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Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo

Cancer patients can harbor significant numbers of CD8 and CD4 T cells with specificities to tumor antigens (Ags). Yet, in most cases, such T cells fail to eradicate the tumor in vivo. Here, we investigated the interference of Ag-specific CD4(+)CD25(+) regulatory T cells (Treg) with the tumor-specifi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chen, Mei-Ling, Pittet, Mikaël J., Gorelik, Leonid, Flavell, Richard A., Weissleder, Ralph, von Boehmer, Harald, Khazaie, Khashayarsha
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544311/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15623559/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408197102
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