CD4(+)CD25(+) T regulatory cells control anti-islet CD8(+) T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

Pancreatic lymph node-derived CD4(+)CD25(+) T regulatory (Treg) cells inhibit in situ differentiation of islet-reactive CD8(+) T cells into cytotoxic T lymphocytes, thereby preventing diabetes progression. The mechanism by which these Treg cells suppress anti-islet CD8(+) T cells is unknown. Here, w...

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Bibliographic Details
Main Authors: Green, E. Allison, Gorelik, Leonid, McGregor, Catrin M., Tran, Elise H., Flavell, Richard A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC196896/
https://ncbi.nlm.nih.gov/pubmed/12949259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1834400100
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