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CD154 is a negative regulator of autoaggressive CD8(+) T cells in type 1 diabetes

TNF/CD80 mice, a CD8(+) T cell-mediated model for type 1 diabetes, transgenically express tumor necrosis factor α (TNF-α) and the costimulatory molecule CD80 in their pancreatic islets. Here we show that these molecules bypass the need for CD40–CD154 costimulatory interactions in activation of CD8(+...

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Detalhes bibliográficos
Main Authors: McGregor, Catrin M., Schoenberger, Stephen P., Green, E. Allison
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC438979/
https://ncbi.nlm.nih.gov/pubmed/15192149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402807101
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