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CD154 is a negative regulator of autoaggressive CD8(+) T cells in type 1 diabetes
TNF/CD80 mice, a CD8(+) T cell-mediated model for type 1 diabetes, transgenically express tumor necrosis factor α (TNF-α) and the costimulatory molecule CD80 in their pancreatic islets. Here we show that these molecules bypass the need for CD40–CD154 costimulatory interactions in activation of CD8(+...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC438979/ https://ncbi.nlm.nih.gov/pubmed/15192149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402807101 |
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