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Single molecule detection of intermediates during botulinum neurotoxin translocation across membranes

The dynamics of Clostridium botulinum neurotoxins (BoNTs) protein-translocation across membranes was investigated by using a single molecule assay with millisecond resolution on excised patches of neuronal cells. Translocation of BoNT/A light chain (LC) by heavy chain (HC) was observed in real time...

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Bibliografiske detaljer
Main Authors: Fischer, Audrey, Montal, Mauricio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965533/
https://ncbi.nlm.nih.gov/pubmed/17563359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700046104
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