Nuclear Lamin A/C Deficiency Induces Defects in Cell Mechanics, Polarization, and Migration

Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse embryonic fibroblasts (Lmna(−/−) MEFs) diminishes the ability of these cells to polarize at the edge of a wound and signifi...

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Hlavní autoři: Lee, Jerry S. H., Hale, Christopher M., Panorchan, Porntula, Khatau, Shyam B., George, Jerry P., Tseng, Yiider, Stewart, Colin L., Hodzic, Didier, Wirtz, Denis
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2007
Témata:
Cell Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965451/
https://ncbi.nlm.nih.gov/pubmed/17631533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.102426
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