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Nuclear Lamin A/C Deficiency Induces Defects in Cell Mechanics, Polarization, and Migration
Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse embryonic fibroblasts (Lmna(−/−) MEFs) diminishes the ability of these cells to polarize at the edge of a wound and signifi...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Biophysical Society
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1965451/ https://ncbi.nlm.nih.gov/pubmed/17631533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.102426 |
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