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Nuclear Lamin A/C Deficiency Induces Defects in Cell Mechanics, Polarization, and Migration
Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse embryonic fibroblasts (Lmna(−/−) MEFs) diminishes the ability of these cells to polarize at the edge of a wound and signifi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1965451/ https://ncbi.nlm.nih.gov/pubmed/17631533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.102426 |
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