Sequence-independent DNA binding and replication initiation by the human origin recognition complex

We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds preferentially to synthetic AT-rich polydeoxynucleotides, but does not effectively discriminate between natural DNA fragment...

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Dettagli Bibliografici

Pubblicato in:	Genes Dev
Autori principali:	Vashee, Sanjay, Cvetic, Christin, Lu, Wenyan, Simancek, Pamela, Kelly, Thomas J., Walter, Johannes C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2003
Soggetti:	Research Papers
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196240/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1084203
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