Sequence-independent DNA binding and replication initiation by the human origin recognition complex

We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds preferentially to synthetic AT-rich polydeoxynucleotides, but does not effectively discriminate between natural DNA fragment...

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Détails bibliographiques
Auteurs principaux: Vashee, Sanjay, Cvetic, Christin, Lu, Wenyan, Simancek, Pamela, Kelly, Thomas J., Walter, Johannes C.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2003
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC196240/
https://ncbi.nlm.nih.gov/pubmed/12897055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1084203
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