Sequence-independent DNA binding and replication initiation by the human origin recognition complex

We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds preferentially to synthetic AT-rich polydeoxynucleotides, but does not effectively discriminate between natural DNA fragment...

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Détails bibliographiques

Publié dans:	Genes Dev
Auteurs principaux:	Vashee, Sanjay, Cvetic, Christin, Lu, Wenyan, Simancek, Pamela, Kelly, Thomas J., Walter, Johannes C.
Format:	Artigo
Langue:	Inglês
Publié:	Cold Spring Harbor Laboratory Press 2003
Sujets:	Research Papers
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196240/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1084203
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