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Sequence-independent DNA binding and replication initiation by the human origin recognition complex
We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this activity is modestly stimulated by ATP. HsORC binds preferentially to synthetic AT-rich polydeoxynucleotides, but does not effectively discriminate between natural DNA fragment...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196240/ https://ncbi.nlm.nih.gov/pubmed/12897055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1084203 |
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