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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and 4EBP1. These functions of TSC1/TSC2 are likely mediated by mTOR. Here we report that TSC2 is a GTPase-acti...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196227/ https://ncbi.nlm.nih.gov/pubmed/12869586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1110003 |
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