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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
Miscoordination of growth and proliferation with the cellular stress response can lead to tumorigenesis. Mammalian target of rapamycin (mTOR), a central cell growth controller, is highly activated in some malignant neoplasms, and its clinical implications are under extensive investigation. We show t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2099465/ https://ncbi.nlm.nih.gov/pubmed/17962806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601900 |
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