Werner syndrome protein limits MYC-induced cellular senescence

The MYC oncoprotein is a transcription factor that coordinates cell growth and division. MYC overexpression exacerbates genomic instability and sensitizes cells to apoptotic stimuli. Here we demonstrate that MYC directly stimulates transcription of the human Werner syndrome gene, WRN, which encodes...

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Bibliografiske detaljer

Udgivet i:	Genes Dev
Principais autores:	Grandori, Carla, Wu, Kou-Juey, Fernandez, Paula, Ngouenet, Celine, Grim, Jonathan, Clurman, Bruce E., Moser, Michael J., Oshima, Junko, Russell, David W., Swisshelm, Karen, Frank, Scott, Amati, Bruno, Dalla-Favera, Riccardo, Monnat, Raymond J.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Cold Spring Harbor Laboratory Press 2003
Fag:	Research Communications
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12842909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1100303
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