Werner syndrome protein limits MYC-induced cellular senescence

The MYC oncoprotein is a transcription factor that coordinates cell growth and division. MYC overexpression exacerbates genomic instability and sensitizes cells to apoptotic stimuli. Here we demonstrate that MYC directly stimulates transcription of the human Werner syndrome gene, WRN, which encodes...

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Номзүйн дэлгэрэнгүй

-д хэвлэсэн:	Genes Dev
Үндсэн зохиолчид:	Grandori, Carla, Wu, Kou-Juey, Fernandez, Paula, Ngouenet, Celine, Grim, Jonathan, Clurman, Bruce E., Moser, Michael J., Oshima, Junko, Russell, David W., Swisshelm, Karen, Frank, Scott, Amati, Bruno, Dalla-Favera, Riccardo, Monnat, Raymond J.
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Cold Spring Harbor Laboratory Press 2003
Нөхцлүүд:	Research Communications
Онлайн хандалт:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12842909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1100303
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