Werner syndrome protein limits MYC-induced cellular senescence

The MYC oncoprotein is a transcription factor that coordinates cell growth and division. MYC overexpression exacerbates genomic instability and sensitizes cells to apoptotic stimuli. Here we demonstrate that MYC directly stimulates transcription of the human Werner syndrome gene, WRN, which encodes...

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Dades bibliogràfiques

Publicat a:	Genes Dev
Autors principals:	Grandori, Carla, Wu, Kou-Juey, Fernandez, Paula, Ngouenet, Celine, Grim, Jonathan, Clurman, Bruce E., Moser, Michael J., Oshima, Junko, Russell, David W., Swisshelm, Karen, Frank, Scott, Amati, Bruno, Dalla-Favera, Riccardo, Monnat, Raymond J.
Format:	Artigo
Idioma:	Inglês
Publicat:	Cold Spring Harbor Laboratory Press 2003
Matèries:	Research Communications
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12842909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1100303
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