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Werner syndrome protein limits MYC-induced cellular senescence

The MYC oncoprotein is a transcription factor that coordinates cell growth and division. MYC overexpression exacerbates genomic instability and sensitizes cells to apoptotic stimuli. Here we demonstrate that MYC directly stimulates transcription of the human Werner syndrome gene, WRN, which encodes...

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Publicado en:Genes Dev
Principais autores: Grandori, Carla, Wu, Kou-Juey, Fernandez, Paula, Ngouenet, Celine, Grim, Jonathan, Clurman, Bruce E., Moser, Michael J., Oshima, Junko, Russell, David W., Swisshelm, Karen, Frank, Scott, Amati, Bruno, Dalla-Favera, Riccardo, Monnat, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196129/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12842909/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1100303
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