Werner syndrome protein limits MYC-induced cellular senescence

The MYC oncoprotein is a transcription factor that coordinates cell growth and division. MYC overexpression exacerbates genomic instability and sensitizes cells to apoptotic stimuli. Here we demonstrate that MYC directly stimulates transcription of the human Werner syndrome gene, WRN, which encodes...

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Vydáno v:	Genes Dev
Hlavní autoři:	Grandori, Carla, Wu, Kou-Juey, Fernandez, Paula, Ngouenet, Celine, Grim, Jonathan, Clurman, Bruce E., Moser, Michael J., Oshima, Junko, Russell, David W., Swisshelm, Karen, Frank, Scott, Amati, Bruno, Dalla-Favera, Riccardo, Monnat, Raymond J.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Cold Spring Harbor Laboratory Press 2003
Témata:	Research Communications
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12842909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1100303
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Werner syndrome protein limits MYC-induced cellular senescence

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