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Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

MAPK signaling pathways function as critical regulators of cellular differentiation, proliferation, stress responsiveness, and apoptosis. One branch of the MAPK signaling pathway that culminates in ERK1/2 activation is hypothesized to regulate the growth and adaptation of the heart to both physiolog...

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Autors principals: Purcell, Nicole H., Wilkins, Benjamin J., York, Allen, Saba-El-Leil, Marc K., Meloche, Sylvain, Robbins, Jeffrey, Molkentin, Jeffery D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955824/
https://ncbi.nlm.nih.gov/pubmed/17709754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610906104
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