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Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

MAPK signaling pathways function as critical regulators of cellular differentiation, proliferation, stress responsiveness, and apoptosis. One branch of the MAPK signaling pathway that culminates in ERK1/2 activation is hypothesized to regulate the growth and adaptation of the heart to both physiolog...

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Detalles Bibliográficos
Main Authors: Purcell, Nicole H., Wilkins, Benjamin J., York, Allen, Saba-El-Leil, Marc K., Meloche, Sylvain, Robbins, Jeffrey, Molkentin, Jeffery D.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955824/
https://ncbi.nlm.nih.gov/pubmed/17709754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610906104
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