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Antitumor Agents. 256. Conjugation of Paclitaxel with Other Antitumor Agents: Evaluation of Novel Conjugates as Cytotoxic Agents

Fifteen different taxoid conjugates were prepared by linking various anticancer compounds, including camptothecin (CPT), epipodophyllotoxin (EP), colchicine (COL), and glycyrrhetinic acid (GA), at the 2’- or 7-position on paclitaxel (TXL, 1) through an ester, imine, amine, or amide bond. Newly synth...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nakagawa-Goto, Kyoko, Nakamura, Seikou, Bastow, Kenneth F., Nyarko, Alexander, Peng, Chieh-Yu, Lee, Fang-Yu, Lee, Fang-Chen, Lee, Kuo-Hsiung
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955431/
https://ncbi.nlm.nih.gov/pubmed/17350834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.02.051
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