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Antitumor Agents 259. Design, Syntheses and Structure-Activity-Relationship Study of Desmosdumotin C Analogs

Desmosdumotin C (1) and its analogs previously showed potent, selective in vitro anticancer activity. To explore structure-activity-relationships of 1 and further increase potency and selectivity, fifteen novel analogs (7–15 and 21–26) were synthesized, and evaluated for cytotoxity against several h...

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Bibliographic Details
Main Authors: Nakagawa-Goto, Kyoko, Chen, Tzu-Hsuan, Peng, Chieh-Yu, Bastow, Kenneth F., Lee, Kuo-Hsiung
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526252/
https://ncbi.nlm.nih.gov/pubmed/17569518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0702534
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