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Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4 and 5
Recently we have demonstrated that replacing His(6) by constrained amino acids in the well known antagonist SHU9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC4 receptors. With the aim to further explore position 6 in the sequence of SHU9119 and MT-II, we have...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1955225/ https://ncbi.nlm.nih.gov/pubmed/17482720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2007.02.012 |
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