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Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation

BACKGROUND: Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's disease and Parkinson's disease. Proteins containing long, homopolymeric stretches of glutamine are especially prone to form aggregates. It has long been known that the small protein...

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Main Authors: Howard, Rebecca A, Sharma, Pratima, Hajjar, Connie, Caldwell, Kim A, Caldwell, Guy A, du Breuil, Rusla, Moore, Rhonda, Boyd, Lynn
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952058/
https://ncbi.nlm.nih.gov/pubmed/17663792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-8-32
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