Characterization of Chimpanzee/Human Monoclonal Antibodies to Vaccinia Virus A33 Glycoprotein and Its Variola Virus Homolog In Vitro and in a Vaccinia Virus Mouse Protection Model

Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human γ1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20...

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Detalhes bibliográficos
Main Authors: Chen, Zhaochun, Earl, Patricia, Americo, Jeffrey, Damon, Inger, Smith, Scott K., Yu, Fujuan, Sebrell, Andrew, Emerson, Suzanne, Cohen, Gary, Eisenberg, Roselyn J., Gorshkova, Inna, Schuck, Peter, Satterfield, William, Moss, Bernard, Purcell, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951440/
https://ncbi.nlm.nih.gov/pubmed/17581986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00906-07
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