Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus

Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human γ1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (K(d) of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of...

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Detalhes bibliográficos
Main Authors: Chen, Zhaochun, Earl, Patricia, Americo, Jeffrey, Damon, Inger, Smith, Scott K., Zhou, Yi-Hua, Yu, Fujuan, Sebrell, Andrew, Emerson, Suzanne, Cohen, Gary, Eisenberg, Roselyn J., Svitel, Juraj, Schuck, Peter, Satterfield, William, Moss, Bernard, Purcell, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413659/
https://ncbi.nlm.nih.gov/pubmed/16436502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510598103
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