Guinea Pig-Adapted Foot-and-Mouth Disease Virus with Altered Receptor Recognition Can Productively Infect a Natural Host

We report that adaptation to infect the guinea pig did not modify the capacity of foot-and-mouth disease virus (FMDV) to kill suckling mice and to cause an acute and transmissible disease in the pig, an important natural host for this pathogen. Adaptive amino acid replacements (I(248)→T in 2C, Q(44)...

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Bibliographic Details
Main Authors: Núñez, José I., Molina, Nicolas, Baranowski, Eric, Domingo, Esteban, Clark, Stuart, Burman, Alison, Berryman, Stephen, Jackson, Terry, Sobrino, Francisco
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951369/
https://ncbi.nlm.nih.gov/pubmed/17522230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00340-07
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