Foot-and-Mouth Disease Virus Forms a Highly Stable, EDTA-Resistant Complex with Its Principal Receptor, Integrin αvβ6: Implications for Infectiousness

The initial stage of foot-and-mouth disease virus (FMDV) infection is virus binding to cell surface integrins via the RGD motif in the GH loop of the VP1 capsid protein. As for all ligand/integrin interactions, the initial contact between FMDV and its integrin receptors is cation dependent and hence...

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Detalhes bibliográficos
Main Authors: DiCara, Danielle, Burman, Alison, Clark, Stuart, Berryman, Stephen, Howard, Mark J., Hart, Ian R., Marshall, John F., Jackson, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224447/
https://ncbi.nlm.nih.gov/pubmed/18045932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01480-07
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