Integrin αvβ8 Functions as a Receptor for Foot-and-Mouth Disease Virus: Role of the β-Chain Cytodomain in Integrin-Mediated Infection

Field isolates of foot-and-mouth disease virus (FMDV) have been shown to use three αv integrins, αvβ1, αvβ3, and αvβ6, as cellular receptors. Binding to the integrin is mediated by a highly conserved RGD motif located on a surface-exposed loop of VP1. The RGD tripeptide is recognized by several othe...

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Detalhes bibliográficos
Main Authors: Jackson, Terry, Clark, Stuart, Berryman, Stephen, Burman, Alison, Cambier, Stephanie, Mu, Dezhi, Nishimura, Stephen, King, Andrew M. Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387692/
https://ncbi.nlm.nih.gov/pubmed/15078934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4533-4540.2004
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