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Guinea Pig-Adapted Foot-and-Mouth Disease Virus with Altered Receptor Recognition Can Productively Infect a Natural Host

We report that adaptation to infect the guinea pig did not modify the capacity of foot-and-mouth disease virus (FMDV) to kill suckling mice and to cause an acute and transmissible disease in the pig, an important natural host for this pathogen. Adaptive amino acid replacements (I(248)→T in 2C, Q(44)...

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מידע ביבליוגרפי
Main Authors: Núñez, José I., Molina, Nicolas, Baranowski, Eric, Domingo, Esteban, Clark, Stuart, Burman, Alison, Berryman, Stephen, Jackson, Terry, Sobrino, Francisco
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951369/
https://ncbi.nlm.nih.gov/pubmed/17522230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00340-07
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