The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections

The cellular prion protein, PrP(C), is neuroprotective in a number of settings and in particular prevents cerebellar degeneration mediated by CNS-expressed Doppel or internally deleted PrP (‘ΔPrP'). This paradigm has facilitated mapping of activity determinants in PrP(C) and implicated a crypti...

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Detalhes bibliográficos
Main Authors: Watts, Joel C, Drisaldi, Bettina, Ng, Vivian, Yang, Jing, Strome, Bob, Horne, Patrick, Sy, Man-Sun, Yoong, Larry, Young, Rebecca, Mastrangelo, Peter, Bergeron, Catherine, Fraser, Paul E, Carlson, George A, Mount, Howard T J, Schmitt-Ulms, Gerold, Westaway, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950727/
https://ncbi.nlm.nih.gov/pubmed/17703189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601830
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