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Synthetic Lethality of Drosophila in the Absence of the MUS81 Endonuclease and the DmBlm Helicase Is Associated With Elevated Apoptosis

Mus81-Mms4 (Mus81-Eme1 in some species) is a heterodimeric DNA structure-specific endonuclease that has been implicated in meiotic recombination and processing of damaged replication forks in fungi. We generated and characterized mutations in Drosophila melanogaster mus81 and mms4. Unlike the case i...

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Détails bibliographiques
Auteurs principaux: Trowbridge, Kirsten, McKim, Kim, Brill, Steven J., Sekelsky, Jeff
Format: Artigo
Langue:Inglês
Publié: Copyright © 2007 by the Genetics Society of America 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950608/
https://ncbi.nlm.nih.gov/pubmed/17603121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.070060
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