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Multiple Functions of Drosophila BLM Helicase in Maintenance of Genome Stability
Bloom Syndrome, a rare human disorder characterized by genomic instability and predisposition to cancer, is caused by mutation of BLM, which encodes a RecQ-family DNA helicase. The Drosophila melanogaster ortholog of BLM, DmBlm, is encoded by mus309. Mutations in mus309 cause hypersensitivity to DNA...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
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Copyright © 2007 by the Genetics Society of America
2007
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950607/ https://ncbi.nlm.nih.gov/pubmed/17507683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.070052 |
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