Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease

The human LINE-1 endonuclease (L1-EN) is the targeting endonuclease encoded by the human LINE-1 (L1) retrotransposon. L1-EN guides the genomic integration of new L1 and Alu elements that presently account for ∼28% of the human genome. L1-EN bears considerable technological interest, because its targ...

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Main Authors: Repanas, Kostas, Zingler, Nora, Layer, Liliana E., Schumann, Gerald G., Perrakis, Anastassis, Weichenrieder, Oliver
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2007
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950540/
https://ncbi.nlm.nih.gov/pubmed/17626046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm516
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