Analysis of 5′ junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5′-end attachment requiring microhomology-mediated end-joining

Insertion of the human non-LTR retrotransposon LINE-1 (L1) into chromosomal DNA is thought to be initiated by a mechanism called target-primed reverse transcription (TPRT). This mechanism readily accounts for the attachment of the 3′-end of an L1 copy to the genomic target, but the subsequent integr...

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Bibliographic Details
Main Authors: Zingler, Nora, Willhoeft, Ute, Brose, Hans-Peter, Schoder, Volker, Jahns, Thomas, Hanschmann, Kay-Martin O., Morrish, Tammy A., Löwer, Johannes, Schumann, Gerald G.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Letters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142468/
https://ncbi.nlm.nih.gov/pubmed/15930490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.3421505
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