Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, accounting for an estimated 600,000 deaths annually. Aberrant methylation, consisting of DNA hypomethylation and/or promoter gene CpG hypermethylation, is implicated in the development of a variety of solid tumors, including H...

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Main Authors: Calvisi, Diego F., Ladu, Sara, Gorden, Alexis, Farina, Miriam, Lee, Ju-Seog, Conner, Elizabeth A., Schroeder, Insa, Factor, Valentina M., Thorgeirsson, Snorri S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950459/
https://ncbi.nlm.nih.gov/pubmed/17717605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31457
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