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BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

To investigate the role of BAX in chemotherapy-induced apoptosis, we transfected the SW626 human ovarian cancer cell line, which lacks functional p53, with a cDNA encoding for murine BAX. Immunoblotting revealed that BAX transfectants expressed a mean of 10-fold increased levels of BAX compared with...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Strobel, Thomas, Swanson, Linda, Korsmeyer, Stanley, Cannistra, Stephen A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19500/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943066/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.14094
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