BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

To investigate the role of BAX in chemotherapy-induced apoptosis, we transfected the SW626 human ovarian cancer cell line, which lacks functional p53, with a cDNA encoding for murine BAX. Immunoblotting revealed that BAX transfectants expressed a mean of 10-fold increased levels of BAX compared with...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Strobel, Thomas, Swanson, Linda, Korsmeyer, Stanley, Cannistra, Stephen A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1996
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.14094
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