Activated Ezrin Promotes Cell Migration through Recruitment of the GEF Dbl to Lipid Rafts and Preferential Downstream Activation of Cdc42

Establishment of polarized cell morphology is a critical factor for migration and requires precise spatial and temporal activation of the Rho GTPases. Here, we describe a novel role of the actin-binding ezrin/radixin/moesin (ERM)-protein ezrin to be involved in recruiting Cdc42, but not Rac1, to lip...

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Auteurs principaux: Prag, Soren, Parsons, Maddy, Keppler, Melanie D., Ameer-Beg, Simon M., Barber, Paul, Hunt, James, Beavil, Andrew J., Calvert, Rosy, Arpin, Monique, Vojnovic, Borivoj, Ng, Tony
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2007
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949366/
https://ncbi.nlm.nih.gov/pubmed/17538024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-11-1031
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