A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway

Binding of microRNA (miRNA) to mRNA within the RNA-induced silencing complex (RISC) leads to either translational inhibition or to destruction of the target mRNA. Both of these functions are executed by Argonaute 2 (Ago2). Using hematopoiesis in mice as a model system to study the physiological func...

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Detalhes bibliográficos
Main Authors: O’Carroll, Dónal, Mecklenbrauker, Ingrid, Das, Partha Pratim, Santana, Angela, Koenig, Ulrich, Enright, Anton J., Miska, Eric A., Tarakhovsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948855/
https://ncbi.nlm.nih.gov/pubmed/17626790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1565607
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