Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

Recent data implicates a role for the CD40–CD40 ligand (CD40L) pathway in graft rejection. One potential mechanism is direct costimulation of T cells through CD40L. Alternatively, the ability of CD40 stimulation to induce CD80 (B7-1) and CD86 (B7-2) expression on antigen-presenting cells (APCs) has...

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Bibliographic Details
Main Authors: Hancock, Wayne W., Sayegh, Mohamed H., Zheng, Xiang-Guang, Peach, Robert, Linsley, Peter S., Turka, Laurence A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1996
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19478/
https://ncbi.nlm.nih.gov/pubmed/8943044
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