Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO(+) pDCs directly activate resting CD4(+)CD25(+)Foxp3(+) Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor...

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Bibliographic Details
Main Authors: Sharma, Madhav D., Baban, Babak, Chandler, Phillip, Hou, De-Yan, Singh, Nagendra, Yagita, Hideo, Azuma, Miyuki, Blazar, Bruce R., Mellor, Andrew L., Munn, David H.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1940240/
https://ncbi.nlm.nih.gov/pubmed/17710230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31911
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