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Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO(+) pDCs directly activate resting CD4(+)CD25(+)Foxp3(+) Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Clinical Investigation
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1940240/ https://ncbi.nlm.nih.gov/pubmed/17710230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31911 |
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