Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO(+) pDCs directly activate resting CD4(+)CD25(+)Foxp3(+) Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sharma, Madhav D., Baban, Babak, Chandler, Phillip, Hou, De-Yan, Singh, Nagendra, Yagita, Hideo, Azuma, Miyuki, Blazar, Bruce R., Mellor, Andrew L., Munn, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1940240/
https://ncbi.nlm.nih.gov/pubmed/17710230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31911
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky